Endocrine Abstracts

Patients: Nineteen acromegalic patients (8 females, 21-69 years-old, with macroadenoma, microadenoma or no evidence of pituitary tumor in 15, 2, 2, respectively) resistant to first generation somatostatin analogs (FG-SA) at high doses and/or intolerant to pegvisomant were switched to pasireotide LAR (PasLAR). Eleven had persistent disease after neurosurgery and two had also undergone radiosurgery (12 and 24 months before starting PasLAR). Six complained of acromegalic headache...

Introduction: Paragangliomas are rare neuroendocrine tumors, that manifest as painless, slow-growing masses, becoming evident only when symptoms of catecholamine overproduction or mass effects emerge. Paragangliomas exhibit a broad spectrum of characteristics, existing as solitary or multiple entities, and may be sporadic or hereditary. These tumors can be either benign or malignant and have origin in the sympathetic or parasympathetic tissues. Paragangliomas are commonly foun...

Background: Among differentiated thyroid cancers, follicular thyroid carcinoma (FTC) is the second most prevalent, representing 10-15% of cases. Histopathological features, tumour size, multifocality, presence of lymphnode metastasis at diagnosis are the most impacting features affecting clinical outcome. Tumour microenvironment (TME) may have an important ancillary role for disease progression. We present two cases of FTC with biochemical and structural persistence of disease...

Parathyroid glands regulate bone metabolism through PTH, while bone modulates parathyroid function through calcium and FGF23. Bone releases the matrix protein osteocalcin (OC), whose hormone function is increasingly evident. We tested the hypothesis that OC may modulate parathyroid function. The 6 hours-stimulation of human parathyroid cells derived from adenomas (PAds) (n = 5) with γ-carboxylated OC (GlaOC; 40–60 ng/ml) increased the expression levels ...